Corpal gastritis in immunised and challenged C57BL/6 mice. Post-immunisation gastritis in short term immunised/challenged mice. Bacterial colonisation and gastric pathology were assessed in control, infected, or immunised/challenged mice one month after challenge with Helicobacter felis or H pylori
| Group | Antrum | Body | Lymphoid aggregates/ follicles | GAIS | Atrophy | Submucosal inflammation | Colonisation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neutrophils | CI | Neutrophils | CI | ||||||||||||||
| H felis | Histology | ||||||||||||||||
| Control infected | 2 (1–3) | 2 (1–3) | 3 (0–5) | 2 (1–4) | 0 (0–1) | 0 (1–10) | 1 (0–3) | 1.5 (0–4) | 3.5 (2–4) | ||||||||
| Immunised/challenged | 3 (2–4)2-150 | 2 (0–3) | 4.5 (4–5)2-150 | 2 (1–3) | 0 (0) | 2.5 (0–11) | 2 (0–3)2-150 | 1.5 (0–3) | 0 (0–3)2-151 | ||||||||
| H pylori | CFUs | ||||||||||||||||
| Control infected | 1 (0–2) | 0 (0–1) | 0 (0–2) | 1 (0–1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 10.1 (6.6) | ||||||||
| Immunised/challenged | 1 (0–3) | 1 (0–2)2-150 | 1.5 (0–2)2-150 | 1 (0–2) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1.1 (1.3)2-152 | ||||||||
CI, chronic inflammation; GAIS, gland active inflammatory score; CFUs, colony forming units, ×10-6/g stomach tissue.
Scores given are median (range), except colony counts forH pylori which are mean (SD).
↵2-150 Significantly greater than the corresponding value in the infected control group (p<0.05; Mann-Whitney);
↵2-151 significantly lower than the corresponding value in the infected control group (p<0.05; Mann-Whitney);
↵2-152 significantly lower than the corresponding value in the infected control group (p<0.01; one way ANOVA).