Characteristics of the individual studies and the overall association between Helicobacter pylori and gastric cancer
| All cases | Controls | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Study | Mean (range) age of cases at diagnosis | Sex ratio among cases (% male) | Median interval (y)1-150 | Total | Hp +ve (%) | Total | Hp +ve (%) | Matched OR | (95% CI) | |
| UK12 23 | 54 (39–69) | 100 | 8.7 | 56 | 67.9 | 174 | 41.4 | 3.471-151 | (1.75–6.85)1-151 | |
| USA (California)4 | 68 (44–90) | 69 | 15.0 | 111 | 84.7 | 111 | 60.4 | 3.701-151 | (1.84–7.44)1-151 | |
| USA (Hawaii)5 | 72 (56–85) | 100 | 13.8 | 109 | 94.5 | 109 | 76.1 | 6.00 | (2.08–17.3) | |
| Taiwan13 | 63 (43–80) | 100 | 2.0 | 29 | 69.0 | 220 | 58.6 | 1.55 | (0.68–3.54) | |
| Finland I14 | 62 (32–85) | 62 | 5.1 | 84 | 86.9 | 146 | 82.9 | 1.50 | (0.70–3.22) | |
| China I15 16 | 63 (49–76) | 100 | 4.8 | 188 | 89.4 | 548 | 82.3 | 1.84 | (1.08–3.11) | |
| Sweden7 | 56 (38–70) | 93 | 5.1 | 56 | 82.1 | 224 | 49.1 | 5.00 | (2.34–10.7) | |
| Japan17 | 69 (46–86) | 58 | 3.6 | 45 | 91.1 | 225 | 75.6 | 3.38 | (1.15–9.90) | |
| Norway18 | 56 (34–68) | 75 | 12.0 | 208 | 79.8 | 983 | 63.0 | 2.26 | (1.55–3.28) | |
| Iceland1-152 | 72 (55–89) | 71 | 15.0 | 41 | 78.0 | 202 | 67.8 | 1.67 | (0.76–3.65) | |
| Finland II1-152 | 63 (52–75) | 100 | 4.1 | 120 | 85.8 | 272 | 69.9 | 2.26 | (1.26–4.05) | |
| China II24 | 61 (36–75) | 62 | 3.6 | 181 | 62.4 | 192 | 51.6 | 1.661-151 | (1.08–2.54) | |
| Total | 62 (32–90) | 82 | 6.0 | 1228 | 81.2 | 3406 | 66.11-153 | 2.36 | (1.98–2.81) | |
↵1-150 Interval between collection of blood sample used forH pylori serology and cancer diagnosis.
↵1-151 Odds ratios (OR) differ from published results due to changes in study sample (UK and California) and use of matching (China II). Published results are UK OR 2.77 (95% confidence interval (CI) 1.04–7.97)15 and OR 4.0 (1.9–8.2)23; California OR 3.6 (1.8–7.3)4; and China II OR 2.0 (1.3–3.2).24
↵1-152 Unpublished data.
↵1-153 Weighted by the number of cases per study to allow for different matching ratios.