Association between Helicbacter pylori infection and non-cardia and cardia gastric cancer2-150 data from 12 prospective studies
| Study | Non-cardia cases | Controls | Matched OR | (95% CI) | Cardia cases | Controls | Matched OR | (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Hp +ve (%) | Total | Hp +ve (%) | Total | Hp +ve (%) | Total | Hp +ve (%) | |||||||
| UK12 23 | 9 | 66.7 | 27 | 44.4 | 2.88 | (0.50–16.5) | 12 | 33.3 | 36 | 30.6 | 1.15 | (0.27–4.91) | ||
| USA (California)4 | 62 | 88.7 | 62 | 61.3 | 5.25 | (1.80–15.3) | 4 | 25.0 | 4 | 25.0 | 1.00 | (0.06–16.0) | ||
| USA (Hawaii)5 | 74 | 95.9 | 74 | 75.7 | 8.50 | (1.96–36.8) | 5 | 40.0 | 5 | 80.0 | —2-152 | — | ||
| Taiwan13 | 21 | 71.4 | 160 | 60.0 | 1.66 | (0.61–4.51) | 8 | 62.5 | 60 | 55.0 | 1.33 | (0.31–5.79) | ||
| Finland I14 | 75 | 88.0 | 130 | 82.3 | 1.74 | (0.75–4.03) | 9 | 77.8 | 16 | 87.5 | 0.59 | (0.08–4.30) | ||
| China I15 16 | 114 | 87.7 | 331 | 82.2 | 1.54 | (0.82–2.89) | 43 | 90.7 | 124 | 87.1 | 1.44 | (0.43–4.92) | ||
| Sweden7 | 27 | 88.9 | 108 | 49.1 | 11.1 | (2.51–49.4) | 13 | 46.2 | 52 | 48.1 | 0.92 | (0.27–3.16) | ||
| Japan17 | 38 | 89.5 | 190 | 73.7 | 3.02 | (1.02–8.91) | 4 | 100 | 20 | 85.0 | —2-152 | — | ||
| Norway18 | 132 | 90.2 | 614 | 62.9 | 5.15 | (2.83–9.37) | 45 | 44.4 | 228 | 64.9 | 0.40 | (0.20–0.77) | ||
| Iceland2-151 | 35 | 77.1 | 176 | 68.8 | 1.52 | (0.66–3.53) | 5 | 80.0 | 22 | 68.2 | 1.68 | (0.18–15.5) | ||
| Finland II2-151 | 93 | 93.5 | 204 | 71.1 | 4.72 | (1.98–11.3) | 27 | 59.3 | 68 | 66.2 | 0.61 | (0.22–1.70) | ||
| China II24 | 82 | 62.2 | 174 | 51.1 | 1.82 | (1.03–3.22) | 99 | 62.6 | 192 | 51.6 | 1.77 | (1.05–2.97) | ||
| Total | 762 | 86.0 | 2250 | 68.62-153 | 2.97 | (2.34–3.77) | 274 | 62.0 | 827 | 61.92-153 | 0.99 | (0.72–1.35) | ||
↵2-150 Excludes all cases known to have had a partial gastrectomy or where the cancer could not be localised to a particular part of the stomach.
↵2-151 Unpublished data.
↵2-152 In the Hawaiian study there were no case control pairs with aH pylori positive case and a negative control; in the Japanese study there were no H pylori negative cases.
↵2-153 Weighted by the number of cases in each study to allow for the different matching ratios of controls to cases.
OR, odds ratio; CI, confidence interval.