Association between Helicobacter pylori infection and non-cardia gastric cancer3-150 by interval between sample collection for H pylori serology and cancer diagnosis, age at diagnosis, sex, and tumour histology3-152
| Cases | Controls | ||||||
|---|---|---|---|---|---|---|---|
| Total | Hp+ve3-151(%) | Total | Hp+ve3-151(%) | Matched OR | (95% CI) | ||
| Interval between sample collection and cancer diagnosis (y) | |||||||
| <5 | 334 | 82.6 | 999 | 66.2 | 2.56 | (1.83–3.57) | |
| 5–9.9 | 205 | 85.4 | 624 | 72.0 | 2.09 | (1.33–3.29) | |
| 10–14.9 | 103 | 95.1 | 293 | 63.1 | 9.56 | (3.77–24.2) | |
| 15+ | 120 | 88.3 | 334 | 65.9 | 4.15 | (2.08–8.29) | |
| <10 | 539 | 83.7 | 1623 | 68.4 | 2.39 | (1.82–3.12) | |
| 10+ | 223 | 91.5 | 627 | 64.6 | 5.93 | (3.41–10.3) | |
| Sex | |||||||
| Male | 625 | 86.4 | 1839 | 68.4 | 2.98 | (2.27–3.90) | |
| Female | 137 | 83.9 | 411 | 62.5 | 2.93 | (1.76–4.88) | |
| Age at diagnosis (y) | |||||||
| <50 | 67 | 89.6 | 251 | 54.2 | 7.10 | (2.93–17.2) | |
| 50–59 | 206 | 87.4 | 718 | 65.2 | 3.94 | (2.46–6.32) | |
| 60–69 | 313 | 82.7 | 886 | 70.9 | 1.98 | (1.40–2.80) | |
| 70+ | 176 | 88.6 | 395 | 71.6 | 3.13 | (1.76–5.56) | |
| Histological type3-152 | |||||||
| Intestinal | 241 | 90.5 | 700 | 65.4 | 4.45 | (2.74–7.24) | |
| Diffuse | 114 | 90.4 | 353 | 69.1 | 3.39 | (1.70–6.76) | |
| Total | 762 | 86.0 | 2250 | 67.3 | 2.97 | (2.34–3.77) | |
↵3-150 Excludes all cases known to have had a partial gastrectomy and cases where the cancer could not be localised to a particular part of the stomach.
↵3-151 Percentages are not directly comparable across strata because different studies contributed different numbers of cases to each stratum.
↵3-152 Information about histological type was only available for seven studies (the two from the USA, the two from Finland, Taiwan, Japan, and Norway).
OR, odds ratio; CI, confidence interval.