Table 4

Association between Helicobacter pylori infection and cardia gastric cancer^4-150 by interval between sample collection for H pylori serology and cancer diagnosis, age at diagnosis, sex, and tumour histology^4-152

	Cases		Controls
	Total	Hp+ve^4-151(%)	Total	Hp+ve^4-151(%)	Matched OR	(95% CI)
Interval between sample collection and cancer diagnosis (y)
<5	133	68.4	340	66.5	1.21	(0.75–1.93)
5–9.9	93	63.4	273	60.4	1.26	(0.73–2.17)
10–14.9	26	42.3	108	60.2	0.48	(0.19–1.20)
15+	22	40.9	106	60.4	0.44	(0.17–1.16)

<10	226	66.4	613	63.8	1.23	(0.86–1.75)
10+	48	41.7	214	60.3	0.46	(0.23–0.90)
Sex
Male	210	61.9	680	63.2	0.98	(0.68–1.40)
Female	64	62.5	147	61.2	1.03	(0.55–1.92)
Age at diagnosis (y)
<50	33	45.5	97	50.5	0.90	(0.37–2.19)
50–59	86	61.6	311	62.1	0.94	(0.55–1.59)
60–69	115	63.5	317	67.5	0.84	(0.52–1.38)
70+	40	72.5	102	62.7	2.23	(0.86–5.80)
Histological type^4-152
Intestinal	70	44.3	278	62.6	0.42	(0.24–0.75)
Diffuse	12	75.0	63	73.0	0.93	(0.21–4.10)

Total	274	62.0	827	62.9	0.99	(0.72–1.35)

↵4-150 Excludes all cases known to have had a partial gastrectomy and cases where the cancer could not be localised to a particular part of the stomach.
↵4-151 Percentages are not directly comparable across strata because different studies contributed different numbers of cases to each stratum.
↵4-152 Information about histological type was only available for seven studies (the two from the USA, the two from Finland, Taiwan, Japan and Norway).
OR, odds ratio; CI, confidence interval.