Controls (n=12) | Cirrhosis (n=20) | p Value | |
COMPart (ml/mm Hg) | 1.06 (0.09) [0.00–1.5] | 1.32 (0.10) [0.5–2.2] | 0.03 |
Arterial blood pressure | |||
Systolic (mm Hg) | 144 (7) [90–185] | 139 (5) [103–175] | NS |
Diastolic (mm Hg) | 72 (3) [56–85] | 61 (2) [48–80] | <0.01 |
Pulse pressure (mm Hg) | 73 (5) [30–100] | 78 (4) [44–105] | NS |
Mean (mm Hg) | 100 (4) [78–115] | 88 (3) [68–120] | 0.02 |
CO (l/min) | 5.74 (0.44) [2.7–7.9] | 7.48 (0.37) [4.34–9.96] | <0.01 |
Heart rate (beat/min) | 75 (4) [50–96] | 79 (3) [56–108] | NS |
Stroke volume (ml) | 77 (5) [39–101] | 97 (6) [60–141] | <0.04 |
Plasma volume (l) | 2.89 (0.17) [2.10–3.95] | 3.82 (0.19) [2.47–5.39] | <0.005 |
(ml/kg) | 45 (3) [31–64] | 55 (2) [41–70] | <0.01 |
Arterial O2 saturation (%) | 98.2 (1.5) [95–100] | 97.0 (1.1) [94–99] | NS |
Arterial O2 tension (kPa) | 11.1 (0.56) [9.2–13] | 11.0 (0.33) [5.7–15] | NS |
Arterial CO2 tension (kPa) | 5.10 (0.18) [4.5–5.8] | 4.34 (0.13) [3.4–5.2] | <0.005 |
Wedged to free hepatic vein pressure (mm Hg) | 3.4 (1.0) [2–6] | 17 (1.5) [5–27] | <0.001 |
Plasma noradrenaline (nmol/l) | 371 [133–663] | 660 (79) [60–1215] | <0.02 |
Plasma adrenaline (nmol/l) | 94 [24–199] | 177 (23) [46–503] | <0.01 |
Plasma renin activity (U/l) | 33 [6–59] | 656 (273) [4–4813] | <0.0001 |
Plasma endothelin 1 (pg/ml) | 1.5 [0.8–2.1] | 7.3 (1.1) [4.3–21.4] | <0.0001 |
Plasma CGRP (pmol/l) | 37 [24–50] | 142 (46) [28–944] | <0.0001 |
Mean (SEM) [range].
COMPart, arterial compliance; CGRP, calcitonin gene related peptide; CO, cardiac output.