Histological grading of villus damage and number of veins containing red blood cells (RBC) in the different series of the present study. Hexamethonium and nifedipine experiments were performed on acutely denervated intestinal segments. For details of measurements see table 1 and text
| Villus damage | Venous RBC | ||||
|---|---|---|---|---|---|
| Series | Control | Toxin A | Control | Toxin A | |
| Toxin A, 1 μg/ml | |||||
| Acutely denervated (6) | 0.2 (0.2) | 2.1 (0.3)2-a | 2.5 (0.9) | 10.8 (1.2)2-a | |
| Chronically denervated (5) | 0 (0) | 0.2 (0.2)2-b | 3.3 (1.3) | 5.2 (1.8)a b | |
| Hexamethonium (5) | 0.3 (0.3) | 1.2 (0.4)a b c | 3.3 (0.9) | 3.4 (1.3)2-b | |
| Nifedipine (6) | 0 (0) | 1.8 (0.5)a c | 4.7 (1.4) | 3.3 (0.7)2-b | |
| Toxin A, 15 μg/ml | |||||
| Acutely denervated (6) | 0 (0) | 2.8 (0.2)2-a | 3.4 (1.2) | 8.8 (1.1)2-a | |
| Chronically denervated (5) | 0 (0) | 2.2 (0.3)a d | 2.7 (0.5) | 4.2 (1.0)b | |
Numbers in parentheses indicate number of observations.
↵2-a Statistically significant compared with control;
↵2-b statistically significant compared with acutely denervated;
2-c statistically significant compared with chronically denervated;
2-d statistically significant compared with corresponding group of toxin A, 1 μg/ml.