Simulations created with Gensim and analysed with Genehunter. Successive simulations were performed with increasing proportion of affected sibling pairs generated randomly (that is, not linked to presumed locus)
| % Linked | Avg MLS | No sims MLS >3.6 | % Loss |
| (a) Presumed locus with λs=3.5 | |||
| 100% | 6.28 | 900 | NA |
| 95% | 5.67 | 882 | 2.0 |
| 90% | 5.29 | 792 | 12.0 |
| 80% | 4.17 | 603 | 33.0 |
| (b) Presumed locus with λs=1.8 | |||
| 100% | 4.84 | 828 | NA |
| 95% | 4.49 | 645 | 22.1 |
| 90% | 4.21 | 593 | 28.4 |
| 80% | 3.50 | 428 | 48.3 |
| (c) Presumed locus with λs=1.3 | |||
| 100% | 3.28 | 368 | NA |
| 95% | 3.06 | 296 | 19.6 |
| 90% | 2.76 | 220 | 40.2 |
| 80% | 2.39 | 158 | 57.1 |
λs , relative risk in sibling versus general population risk.
% Linked, per cent of affected sibling pairs linked to presumed locus.
Avg MLS, average multipoint LOD score seen in 100 (a), 200 (b), or 500 (c) affected sibling pairs after 1000 replicates.
No sims MLS >3.6, number/1000 simulations where the multipoint LOD score reached a threshold of 3.6.
% Loss, per cent fewer simulations that reached a threshold of 3.6.
NA, not applicable.