Details of patients studied
| Endocopically evaluable patients | ||||||
|---|---|---|---|---|---|---|
| All patients randomised (n (%)) | All (n (%)) | Placebo | Lansoprazole | Tranexamic acid | Both drugs | |
| n | 414 | 228 | 55 | 58 | 57 | 58 |
| Age (y) (mean (SD)) | 58.4 (19.9) | 58.9 (19.3) | 56.2 | 58.8 | 60.3 | 60.2 |
| Female | 163 (39.4) | 88 (38.6) | 23 | 20 | 23 | 22 |
| Past history PU | 130 (24.9) | 64 (28.1) | 13 | 19 | 17 | 15 |
| Drugs on admission | ||||||
| Ulcer healing | 97 (23.5) | 50 (21.9) | 14 | 8 | 14 | 14 |
| NSAIDs | 144 (35.0) | 87 (37.3) | 18 | 15 | 27 | 27 |
| Other | 264 (64.2) | 151 (66.8) | 31 | 41 | 41 | 38 |
| High risk patient | 68 (16.4) | 35 (15.4) | 7 | 11 | 9 | 8 |
| Endoscopic diagnosis | ||||||
| Peptic ulcer | 141 (37.2) | 98 (42.9) | 22 | 20 | 32 | 24 |
| Oesophageal | 14 (3.7) | 11 (4.8) | 1 | 3 | 4 | 3 |
| Gastric | 53 (14.0) | 37 (16.2) | 9 | 8 | 9 | 11 |
| Pyloric/duodenal | 74 (19.5) | 50 (21.9) | 12 | 9 | 19 | 10 |
| Erosions | 77 (20.3) | 48 (21.1) | 12 | 11 | 13 | 12 |
| Oesophageal | 32 (8.4) | 17 (7.5) | 5 | 4 | 2 | 6 |
| Gastric | 26 (6.9) | 15 (6.6) | 2 | 3 | 5 | 5 |
| Pyloric/duodenal | 19 (5.0) | 16 (7.0) | 5 | 4 | 6 | 1 |
| Mallory Weiss tear | 24 (6.3) | 15 (6.6) | 6 | 4 | 2 | 3 |
| Oesophageal varices | 14 (3.7) | 9 (3.9) | 4 | 4 | 0 | 1 |
| Normal | 65 (17.2) | 14 (6.1) | 2 | 4 | 2 | 6 |
| Other1-150 or cause unclear | 58 (15.3) | 44 (19.3) | 9 | 15 | 8 | 12 |
| Endoscopic findings | ||||||
| Blood in stomach | 107 (25.8) | 78 (34.2) | 29 | 15 | 19 | 15 |
| Fresh | 48 (11.6) | 37 (16.2) | 12 | 12 | 6 | 7 |
| Definite active bleeding | 40 (9.7) | 32 (14.0) | 12 | 8 | 7 | 5 |
| Stigmata of recent haemorrhage | 116 (28.0) | 87 (38.2) | 20 | 24 | 24 | 19 |
Values are number or number (%).
↵1-150 Including hiatus hernia, Dieulafoy's lesion, malignancy, and lower gastrointestinal bleeding.
PU, peptic ulcer.