Prevalence of each autoimmune (AI) disease among coeliac disease (CD) patients and controls: 151 AI diseases in 127 of 422 patients (30%) (multiple AI diseases occurred in single patients); 70 AI diseases in 605 controls (11.57%) (p<0.00001). Excluding dermatits herpetiformis, the prevalence of AI diseases resulted in 111 AI diseases in 91 of 422 patients (21.5%) (p=0.00001 compared with controls)
| AI diseases |
CD
patients (n (%)) |
Controls (n (%)) | χ2 test (p value) |
| IDDM | 16 (3.79) | 2 (0.33) | 15.341 (<0.0005) |
| Dermatits herpetiformis | 42 (9.95) | 0 (0) | 60.269 (<0.0001) |
| AI thyroid diseases | 57 (13.5) | 12 (2) | 50.852 (<0.0001) |
| AI hepatitis | 2 (0.5) | 1 (0.16) | 0.952 (NS) |
| AI atrophic gastritis | 3 (0.71) | 0 (0) | 2.218 (NS) |
| AI anaemia, neutropenia, thrombocytopenia | 7 (1.65) | 1 (0.16) | 5.371 (=0.0218) |
| Connective tissue diseases | 7 (1.65) | 15 (3.19) | 0.455 (NS) |
| Psoriasis | 13 (3.08) | 36 (5.95) | 3.897 (=0.0488) |
| Alopecia | 1 (0.24) | 3 (0.5) | 0.021 (NS) |
| Epilepsy with occipital calcifications | 3 (0.7) | 0 (0) | 2.218 (NS) |
IDDM, insulin dependent diabetes mellitus.