Effects of topical NG-monomethyl-l-arginine (l-NMMA) and l-arginine (l-Arg) on colonic net fluid transfer and output of nitrite/nitrate (NOx ) in patients with collagenous colitis during perfusion of whole colon
| Net fluid transfer (ml/min) | NOx output (nmol/min) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient | Basal | l-NMMA | Δ | Basal | l-Arg | Δ | Basal | l-NMMA | Δ | Basal | l-Arg | Δ | |
| MS | +0.66 | −0.15 | −0.81 | +0.43 | +0.94 | +0.51 | +132 | + 52 | −80 | +93 | +161 | +68 | |
| KL | +0.68 | +0.42 | −0.26 | +0.60 | +0.96 | +0.35 | +161 | + 85 | −76 | +188 | +220 | +32 | |
| IS | +0.11 | −0.18 | −0.29 | −0.10 | +0.10 | +0.20 | +486 | +356 | −130 | + 91 | +115 | +24 | |
| IH | +1.31 | +0.82 | −0.49 | +1.31 | +1.51 | +0.20 | +352 | +187 | −165 | +268 | +314 | +46 | |
| GF | +0.54 | −0.16 | −0.70 | +0.28 | +0.40 | +0.12 | +187 | +178 | −10 | +199 | +204 | + 5 | |
| JK | +0.71 | +0.57 | −0.14 | — | — | — | +379 | +170 | −209 | — | — | — | |
| Grand mean | +0.67 (0.16) | +0.22 (0.18)2-150 | −0.45 (0.11) | +0.50 (0.23) | +0.78 (0.25)† | +0.28 (0.07) | +283 (58) | +171 (43)2-150 | −112 (29) | +168 (34) | +203 (33)† | +35 (11) | |
Individual and mean (SEM) values are given. Two studies were performed in each patient (with the exception of patient JK), which is why a basal value is given for both l-NMMA andl-arginine treatment. Positive values indicate output of NOx or secretion of fluid and negative values indicate absorption.
↵2-150 p<0.01 or †p<0.03 compared with basal period.