Haemodynamic studies in control and galactosamine (GalN) rats treated with Bosentan
| Treatment | MAP (mm Hg) | RBF (ml/min/kidney) | RVR (mm Hg/ml/min) |
|---|---|---|---|
| Values are mean (SEM). | |||
| There were no significance differences in mean arterial pressure (MAP). Renal blood flow (RBF) and renal vascular resistance (RVR) were decreased and increased, respectively, in rats with GalN induced liver/renal failure (***p<0.0001). Bosentan had no effect on renal blood flow or renal vascular resistance in either control animals or those with liver failure. | |||
| Control (n=12) | 115 (3.8) | 2.9 (0.2) | 44 (4) |
| GalN (n=12) | 106 (5) | 1.8 (0.2)*** | 69 (9)*** |
| Control+Bos (n=4) | 113 (5) | 2.7 (0.5) | 46 (9) |
| GalN+Bos (n=6) | 118 (7) | 2.0 (0.4)*** | 72 (15)*** |