Table 1

Clinical characteristics and diagnostic findings

Patient No
1 2 3 4
Age (y)39434347
SexFFFF
Ethnic backgroundChineseCaucasianCaucasianCaucasian
Laboratory values
 AMAPositive 1:10240Positive 1:10240Positive 1:1280Negative
 M-2 antibodyPositivePositivePositiveNegative
 ANAPositive 1:40Positive 1:80NegativePositive 1:640
 Total bilirubin (μmol/l; normal <18)7877168129
 APh (U/l; normal <75)709926761848
 ALT (U/l; normal <50)33628756194
 IgG (g/l; normal <15.5)22.914.310.613.6
 IgM (g/l; normal <2.8)4.074.134.529.19
 Bile salts (μmol/l; normal <10)840240400720
 Cholesterol (mmol/l; normal <6.5)11.38.632.616.0
 TSH (mU/l; normal=0.20–4.20)0.540.681.230.97
 LD (U/l; normal <480)308345221364
Radiology
 Endoscopic cholangiographynaNo stenosesNo stenosesNo stenoses
 Abdominal ultrasonographyNormalNormalNormalNormal
 Spleen size at US (cm)Not enlarged9–101215
Visual liver assessmentnaNormalNormalNormal
Revised AIH score+8+8+2+8
Upper GI endoscopynaNo phNo phNo ph
  • Data obtained at the time of liver biopsy, as indicated in the text.

  • na, not available; GI, gastrointestinal; ph, portal hypertension; AMA, antimitochondrial antibodies; M-2 antibody, (ELISA test) antibody directed against the E2 subunit of mitochondrial pyruvate dehydrogenase; ANA, antinuclear antibodies; APh, alkaline phosphatase; ALT, alanine aminotransferase; IgG, immunoglobulin G; IgM, immunoglobulin M; TSH, thyroid stimulating hormone; LD, lactate dehydrogenase.