Sex related differences in the human mucosal glutathione (GSH) system in the antrum and duodenum†
| GSH parameter | Males (n=104) | Females (n=98) |
|---|---|---|
| Values are mean (SEM). | ||
| †Matched for endoscopic diagnosis. | ||
| **Significantly different from antral value in males, p<0.01. | ||
| GST, glutathione S-transferase; GSTA, glutathione S-transferase alpha; GSTP, glutathione S-transferase pi. | ||
| GSH content (nmol/mg protein) | ||
| Antrum | 21.2 (0.8) | 24.8 (1.0)** |
| Duodenum | 34.2 (1.4) | 36.2 (1.2) |
| GST activity (nmol/min/mg protein) | ||
| Antrum | 576 (21) | 679 (32)** |
| Duodenum | 813 (30) | 851 (33) |
| GSTA content (μg/mg protein) | ||
| Antrum | 4.2 (0.5) | 4.8 (0.7) |
| Duodenum | 20.4 (1.0) | 19.5 (1.0) |
| GSTP content (μg/mg protein) | ||
| Antrum | 15.3 (0.9) | 17.7 (1.1) |
| Duodenum | 11.3 (0.7) | 11.1 (0.7) |