Distribution of various clinical parameters among patients with chronic pancreatitis groped according to the results of mutational screening for the SPINK1 and PRSS1 genes
| SPINK1 | PRSS1 | Mutation negative | |
|---|---|---|---|
| Results from the PRSS1 and SPINK1 gene analysis were used to divide the cohort of chronic pancreatitis: SPINK1, patients who had at least one mutated SPINK1 allele (N34S and/or P55S); PRSS1, patients who had the N29I or R122H PRSSI mutation; Mutation negative, patients who did not have one of the mentioned mutations (wild-type). | |||
| Percentages refer to the proportion of patients within each given group. | |||
| Type A pain represents recurrent pain attacks while type B pain indicates unrelenting continuous pain. | |||
| Demographics | |||
| n | 14 | 6 | 95 |
| Sex (M/F) | 10/4 | 0/6 | 61/34 |
| Age (y) | 41 (12) | 26 (7) | 49 (11) |
| Age of onset (y) | 26 (18) | 6 (5) | 38 (11) |
| Duration of symptoms (y) | 14 (8) | 20 (9) | 11 (9) |
| Cause | |||
| Alcoholic | 5 (36%) | 67 (71%) | |
| Idiopathic | 5 (36%) | 19 (20%) | |
| Familial | 2 (14%) | 6 (100%) | 2 (2%) |
| Annular pancreas | 1 (7%) | ||
| Pancreas divisum | 4 (4%) | ||
| Trauma | 3 (3%) | ||
| Hyperparathyroidism | 1 (7%) | ||
| Hospital admissions | |||
| Average number of hospitalisations per patient | 5 | 16 | 4 |
| Total number of hospitalisations | 70 | 95 | 271 |
| Clinical characteristics | |||
| Smoking | 8 (57%) | 3 (50%) | 69 (73%) |
| Pancreatic pseudocysts | 7 (50%) | 1 (17%) | 42 (44%) |
| Pancreatic duct abnormalities | 7 (50%) | 1 (17%) | 46 (48%) |
| Diabetes mellitus | 7 (50%) | 0 | 30 (31%) |
| Steatorrhoea | 7 (50%) | 1 (17%) | 34 (35%) |
| Pain | |||
| A | 5 (36%) | 2 (40%) | 25 (26%) |
| B | 8 (57%) | 2 (40%) | 52 (54%) |
| Therapy | |||
| Narcotics | 11 (79%) | 6 (100%) | 69 (72%) |
| Pancreatic surgery | 11 (79%) | 3 (50%) | 70 (73%) |
| Splanchnic nerve denervation | 4 (29%) | 2 (33%) | 31 (33%) |