Table 1

Agents influencing hepatic stellate cell contractility

AgentEffectProposed mechanism
PG, prostaglandin; NO, nitric oxide; ANP, atrial natriuretic peptide.
Endothelin-1Contraction[Ca2+]i
ThrombinContraction[Ca2+]i
Angiotensin IIContraction[Ca2+]i
VasopresssinContraction[Ca2+]i
AdenosineContraction[Ca2+]i ?
Substance PContraction[Ca2+]i
Leukotriene D4Contraction[Ca2+]i
PGF2/thromboxaneContraction[Ca2+]i
Lysophosphatidic acidContractionRho kinase
NORelaxationcGMP
ANPRelaxationcGMP/[Ca2+]i
AdrenomedullinRelaxationcAMP
SomatostatinRelaxation[Ca2+]i,/rho kinase?
Agents increasing cAMP/cGMPRelaxationcAMP/cGMP
PGI2/PGE2RelaxationcAMP
Y-27632 (rho kinase inhibitor)RelaxationRho kinase