Frequency (n (%)) of methylenetetrahydrofolate reductase (MTHFR) genotypes (CC, CT, and TT) in control subjects and in colorectal cancer (CRC) patient subgroups
| n | CC (%) | CT (%) | TT (%) | p Value | |
|---|---|---|---|---|---|
| p values for χ2 test comparing proportions of CC and TT between groups. | |||||
| *The ≥60 year group was used as age matched controls for microsatellite instability positive (MSI+) cases as 80% of these patients were aged 60 years or more. | |||||
| Controls | 1207 | 533 (44) | 560 (47) | 114 (9) | |
| CRC cases | 501 | 249 (50) | 197 (39) | 55 (11) | 0.70 |
| Controls <70 y | 980 | 425 (43) | 456 (47) | 99 (10) | |
| Controls ≥70 y | 227 | 108 (48) | 104 (46) | 15 (7) | 0.08 |
| CRC cases <70 y | 242 | 135 (55) | 84 (35) | 23 (10) | |
| CRC cases ≥70 y | 259 | 114 (44) | 113 (44) | 32 (12) | 0.10 |
| Controls <70 y | 980 | 425 (43) | 456 (47) | 99 (10) | |
| Cases <70 y | 242 | 135 (55) | 84 (35) | 23 (10) | 0.25 |
| Controls ≥70y | 227 | 108 (48) | 104 (46) | 15 (7) | |
| Cases ≥70 y | 259 | 114 (44) | 113 (44) | 32 (12) | 0.03 |
| Controls ≥60 y* | 467 | 204 (44) | 229 (49) | 34 (7) | |
| MSI+ cases | 75 | 28 (37) | 35 (47) | 12 (16) | 0.03 |