Median age at diagnosis for colorectal cancer (CRC) patient subgroups according to methylenetetrahydrofolate reductase (MTHFR) genotype
| Age (y) at diagnosis | |||||
|---|---|---|---|---|---|
| n | CC | CT | TT | p Value* | |
| Values are median (range). | |||||
| MSI+, microsatellite instability positive. | |||||
| *p values for U test comparing median ages of CC versus TT. | |||||
| †p value for U test comparing median ages of TT between MSI+ and MSI− proximal CRCs. | |||||
| ‡p value for U test comparing median ages of TT between MSI− CRCs from the proximal and distal colon. | |||||
| MSI+ proximal | 75 | 67 (34–89) | 72 (38–89) | 78 (56–91) | 0.04 |
| MSI− proximal | 203 | 68 (34–92) | 73 (49–100) | 74 (51–91) | 0.06 |
| p=0.5† | |||||
| MSI− distal | 223 | 67 (32–89) | 69 (39–91) | 67 (32–81) | 0.46 |
| p=0.03‡ | |||||