Table 2

Median age at diagnosis for colorectal cancer (CRC) patient subgroups according to methylenetetrahydrofolate reductase (MTHFR) genotype

Age (y) at diagnosis
nCCCTTTp Value*
Values are median (range).
MSI+, microsatellite instability positive.
*p values for U test comparing median ages of CC versus TT.
†p value for U test comparing median ages of TT between MSI+ and MSI− proximal CRCs.
‡p value for U test comparing median ages of TT between MSI− CRCs from the proximal and distal colon.
MSI+ proximal 7567 (34–89)72 (38–89)78 (56–91)0.04
MSI− proximal20368 (34–92)73 (49–100)74 (51–91)0.06
p=0.5†
MSI− distal22367 (32–89)69 (39–91)67 (32–81)0.46
p=0.03‡