Table 2

Electrophysiological parameters of mouse distal colon before and after application of 100 μM histamine

Vt (mV)Rt (Ω×cm2)Isc (μA/cm2)
TNF-α, tumour necrosis factor α; Vt, transepithelial potential; Isc, short circuit current; Rt, transepithelial resistance.
Effects of addition of 100 μM histamine to the serosal side of the tissues with or without exposure to 50 ng/ml TNF-α over three hours (n=4 for the two groups).
Statistical significance was evaluated using the Student's t test: **p<0.01 compared with control histamine.
Control
    Baseline2.4 (0.6) 35 (5) 67 (8)
    Histamine2.8 (0.7) 31 (4) 88 (13)
    ΔHistamine0.4 (0.1) −4 (1) 21 (5)
TNF-α
    Baseline3.6 (0.6) 51 (11) 77 (12)
    Histamine4.8 (1.0) 38 (7)130 (16)**
    ΔHistamine1.1 (0.2)**−13 (5)** 54 (7)**