Odds ratios of cancer of the colorectum, colon, or rectum for quartiles of serum IGF-1 and IGFBP-3, mutually adjusted
| Quartile | |||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | p for trend | |
| Conditional logistic regression analyses were matched for age, sex, date of blood sampling, fasting status, and time of last food consumption and further adjusted for smoking status. | |||||
| IGF-I, insulin-like growth factor 1; IGFBP, IGF binding protein; OR, odds ratio; CI, confidence interval. | |||||
| IGF-1 adjusted for IGFBP-3 | |||||
| Colorectum | |||||
| OR | 1.00 | 1.18 | 1.18 | 1.27 | 0.56 |
| 95% CI | 0.65–2.14 | 0.60–2.29 | 0.62–2.63 | ||
| Colon | |||||
| OR | 1.00 | 1.81 | 2.16 | 2.47 | 0.08 |
| 95% CI | 0.83–3.98 | 0.91–5.14 | 0.93–6.53 | ||
| Rectum | |||||
| OR | 1.00 | 0.50 | 0.38 | 0.43 | 0.23 |
| 95% CI | 0.15–1.69 | 0.10–1.41 | 0.11–1.59 | ||
| IGFBP-3 adjusted for IGF-1 | |||||
| Colorectum | |||||
| OR | 1.00 | 0.82 | 1.31 | 1.32 | 0.20 |
| 95% CI | 0.44–1.54 | 0.68–2.54 | 0.66–2.67 | ||
| Colon | |||||
| OR | 1.00 | 0.86 | 1.70 | 1.75 | 0.07 |
| 95% CI | 0.39–1.91 | 0.73–3.94 | 0.72–4.22 | ||
| Rectum | |||||
| OR | 1.00 | 0.79 | 0.81 | 0.58 | 0.45 |
| 95% CI | 0.27–2.30 | 0.25–2.66 | 0.16–2.16 | ||