Spine | Non-vertebral | Hip | |
---|---|---|---|
HRT, hormone replacement therapy; NA, not assessed; ND, not demonstrated; * data inconsistent. | |||
Grade A, meta-analysis or randomised controlled trial or at least one randomised controlled trial. | |||
Grade B, from at least one well designed controlled study without randomisation, from at least one other well designed quasi-experimental study, or from well designed non-experimental descriptive studies, for example, comparative studies, correlation studies, case controlled studies. | |||
Grade C, from expert committee reports/opinions/or clinical experience of authorities. | |||
The tables come from the Royal College of Physician/Bone and Tooth Society updated guidelines on the “Management of osteoporosis”. | |||
Alendronate | A | A | A |
Calcitonin | A* | B | B |
Calcitriol | A* | A* | NA |
Calcium | A | B | B |
Calcium and vitamin D | NA | A | A |
Cyclical etidronate | A | B | B |
HRT | A | A | B |
Raloxifene | A | ND | ND |
Risedronate | A | A | A |
Vitamin D | NA | B | B |