Patient characteristic and effect of sildenafil
| Patient No | Sex | Age | Major symptoms | Manometric features before sildenafil | 1 h after sildenafil 50 mg | Comments |
|---|---|---|---|---|---|---|
| 1 | F | 54 | Heartburn and dysphagia | Nutcracker oesophagus | 3 weeks prn treatment | |
| Corpus amplitudes up to 140 mm Hg | Below 60 mm Hg | Withdrawel because of ineffectiveness | ||||
| Duration of pressure waves up to 10 s | Below 5 s | |||||
| LOS pressure 141 mm Hg | 27 mm Hg | |||||
| 2 | M | 56 | Regurgitation | Primarily oesopageal spasm, 2×Botox | 2 weeks treatment, ineffectiveness | |
| LOS pressure 45 mm Hg | No change | Dizziness | ||||
| 3 | M | 39 | Dysphagia | Vigorous achalasia | 10 days treatment, ineffectiveness | |
| Corpus amplitudes in body 81±20 mm Hg | 34±7 mm Hg 41% | Headaches! | ||||
| LOS pressure 35±10 mm Hg | 17±4 mm Hg 48% | Successful dilatation | ||||
| Relaxation of LOS 40% | 38% | |||||
| 4 | F | 27 | Dysphagia | Hypertensive LOS 60 mm Hg | Below 20 mm Hg | 3 days treatment, ineffectiveness Headaches and fatigue |
| 5 | F | 57 | Dysphagia | Hypertensive LOS: 80 mm Hg | 16 mm Hg | Under 25 mg sildenafil no symptoms. |
| > 4 months. No side effects. | ||||||
| Nifedipine causes dizziness | ||||||
| 6 | F | 37 | Dysphagia | Achalasia | 4 days treatment, no effect | |
| LOS 48 mm Hg | 18 mm Hg | Successful Botox injection | ||||
| 7 | F | 54 | Dysphagia and heartburn | Corpus: segm. simult. contr. 70 mm Hg | No obvious contraction | 10 days treatment, dysphagia improved, however sleep disturbances |
| LOS 76 mm Hg | 10 mm Hg | |||||
| 8 | F | 36 | Dysphagia | Nutcracker: corpus ampl. up to 160 mm Hg | 60 mm Hg | 1 week treatment, dysphagia improved, |
| Duration of pressure wave > 9 s | Below 4 s | However feeling of tightness | ||||
| LOS post-deglutitive >120 mm Hg | LOS 20 mm Hg | in the chest at night | ||||
| 9 | M | 49 | Dysphagia | Achalasia, LOS 71 mm Hg, relax 27% | No change | No treatment |
| 10 | F | 41 | Dysphagia, heartburn, and COPD | Nutcracker: post-deglut. LOS 65 mm Hg | Below 20 mm Hg | >4 weeks, dysphagia and heartburn |
| Corpus amplitudes up to 160 mm Hg | No copus motility detectable | Improved, better effect than diltiazem | ||||
| Duration of pressure wave > 9 s | ||||||
| 11 | M | 56 | Dysphagia | Nutcracker: corpus ampl. up to 300 mm Hg | Below 65 mm Hg | 4 days treatment, no effect |
| Duration of pressure wave up to 19 s | Below 3 s | |||||
| LOS up to 60 mm Hg | LOS 10 mm Hg |