Effect of glucagon-like peptide-1(7–36)amide (GLP-1) on blood glucose and plasma immunoreactivities of gastrointestinal peptides
| Parameter | Saline | GLP-1 0.3 pmol/kg/min | GLP-1 0.9 pmol/kg/min |
|---|---|---|---|
| Mean (SEM) of absolute values (n=11); values for the basal period preceding intravenous infusion of saline or GLP-1 are shown in parentheses. | |||
| *p<0.05 versus saline; †p<0.05 versus GLP-1 0.3 pmol/kg/min. Differences were compared using one way repeated measures ANOVA employing individual mean incremental or decremental values over basal values during the post-drug period. | |||
| GLP-1 (pmol/l) | (2.6 (0.6)) 2.0 (0.2) | (2.5 (0.4)) 11.0 (1.1)* | (2.3 (0.2)) 27.3 (2.0)*† |
| Blood glucose (mg/dl) | (84.9 (1.5)) 84.1 (1.4) | (85.6 (1.8)) 74.9 (2.0)* | (88.6 (1.6)) 67.4 (1.2)*† |
| Insulin (mU/l) | (2.8 (0.4)) 2.8 (0.4) | (3.1 (0.5)) 3.6 (0.6) | (3.5 (0.5)) 3.6 (0.7) |
| Pancreatic polypeptide (pg/ml) | (100.8 (12.8)) 112.8 (14.3) | (93.3 (12.4)) 99.5 (12.2) | (100.7 (13.2)) 91.3 (15.7)* |
| C peptide (pg/ml) | (772.8 (70.2)) 744.5 (72.4) | (906.8 (132.8)) 943.4 (137.6) | (973.2 (123.5)) 1096.1 (105.1) |