Table 2

Follow up of regular colonoscopies as prevention in individuals with an increased risk of colorectal cancer

HNPCCHCCFamily history
Risk group12345678 (TCR)9 (OCR)Total
1, gene carrier; 2, first generation at risk; 3, second generation at risk; 4, family member with a negative mutation test; 5, gene carrier; 6, first generation at risk; 7, second generation at risk; 8, individuals with two close relatives (TCR) with colorectal cancer; 9, one first degree relative (OCR) with colorectal cancer <40 years of age.
Estimated risk of cancer (%)70351757035171530
No colonscopies1511191550102205213315765
No patients (M/F)45 (20/25)48 (27/21)5 (0/5)23 (12/11)4 (1/3)83 (33/50)23 (11/12)64 (16/48)9 (3/6)304 (123/181)
Mean age (y) (M/F)45.7 (46/45)42.9 (40/47)25 (0/25)40.7 (41/41)70.5 (72/70)49.5 (49/50)41.8 (45/39)50 (42/53)37.9 (38/38)46.3 (45/48)
Total No adenomas2613035616810195
Total No carcinomas150001000016
Subjects with adenomas or carcinomas22903224421085
Prevalence (%) (M/F)49 (55/44)19 (26/10)013 (25/0)50 (100/33)29 (39/22)17 (27/8)33 (25/35)028 (34/24)
Mean age at first adenoma (y) (M/F)43.6 (41/46)41.4 (38/53)040 (40/0)67.5 (65/70)51.6 (48/56)45 (46/42)51.1 (48/52)048 (44/52)