Summary of the distribution of the N34S mutation in affected individuals
| Affected individuals (families) | N34S | ||||
|---|---|---|---|---|---|
| Population | Total | Heterozygous | Homozygous | %* | |
| *Percentage of affected individual cases. | |||||
| ICP, idiopathic chronic pancreatitis; t-ICP, true idiopathic chronic pancreatitis; f-ICP, familial idiopathic chronic pancreatitis; HP, hereditary pancreatitis; ACP, alcohol related chronic pancreatitis; mt, mutant; wt, wild-type. | |||||
| All ICP | 94 (91) | 17 | 15 | 2 | 18 |
| t-ICP | 87 (87) | 11 | 9 | 2 | 13 |
| f-ICP | 7 (4) | 6 | 6 | 0 | 86 |
| All HP | 108 (59) | 4 | 4 | 0 | 4 |
| All mt-PRSS1 | 81 (45) | 1 | 1 | 0 | 1 |
| PRSS1: R122H | 53 (29) | 1 | 1 | 0 | 1.9 |
| PRSS1: N29I | 23 (13) | 0 | 0 | 0 | 0 |
| PRSS1: A16V | 5 (3) | 0 | 0 | 0 | 0 |
| All wt PRSS1 | 27 (14) | 3 | 3 | 0 | 11 |
| ACP | 67 (67) | 4 | 4 | 0 | 6 |