Contingency table comparing the incidence of N34S mutations between different study population groups
| Group A | Group B | p Value (Fisher's exact test)* |
|---|---|---|
| *Statistically significant with Bonferroni's correction. | ||
| ICP, idiopathic chronic pancreatitis; t-ICP, true idiopathic chronic pancreatitis; f-ICP, familial idiopathic chronic pancreatitis; HP, hereditary pancreatitis; ACP, alcohol related chronic pancreatitis; wt, wild-type; mt, mutant. | ||
| Values are (number of individuals with the N34S mutation/total number of individuals in the group tested). | ||
| All ICP affected (17/94) | All controls (5/200) | <0.0001* |
| t-ICP affected (11/87) | All controls (5/200) | 0.0013* |
| f-ICP affected (6/7) | All controls (5/200) | <0.0001* |
| t-ICP affected (11/87) | f-ICP affected (6/7) | <0.0001* |
| HP affected: all (4/108) | All controls (5/200) | 0.724 |
| HP affected: mt-PRSS1 (1/81) | All controls (5/200) | 0.677 |
| HP affected: wt-PRSS1 (3/27) | All controls (5/200) | 0.056 |
| All familial pancreatitis (HP plus f-ICP) affected (10/115) | All controls (5/200) | 0.024 |
| Wt PRSS1 (f-ICP and HP) affected (9/34) | All controls (5/200) | <0.0001* |
| ACP (4/67) | All controls (5/200) | 0.235 |
| ICP affected (17/94) | ACP (4/67) | 0.032 |
| ICP affected (17/94) | HP affected: all (4/108) | 0.009 |
| ICP affected (17/94) | HP affected: wt-PRSS1 (3/27) | 0.559 |
| ICP affected (17/94) | HP affected: mt-PRSS1 (1/81) | <0.0001* |
| HP affected: wt-PRSS1 (3/27) | HP affected: mt-PRSS1 (1/81) | 0.047 |
| HP and ICP affected: all (21/202) | HP and ICP unaffected (1/58) | 0.034 |
| Wt PRSS1 (f-ICP and HP) affected (9/34) | wt PRSS1 (f-ICP and HP) unaffected (1/17) | 0.135 |
| f-ICP affected (6/7) | f-ICP unaffected (1/9) | 0.0087 |
| Liverpool controls (4/100) | Münster controls (1/100) | 0.369 |