VIGOR and CLASS compared
| VIGOR Rofecoxib 50 mg | CLASS Celecoxib 400 mg twice daily | |
|---|---|---|
| Patients | 8076 RA | 8059 OA (72%) + RA |
| Aspirin | No | ≤325 mg (21%) |
| NSAIDs | Naproxen 1 g | Diclofenac 150 mg Ibuprofen 2.4 g |
| Duration | 9.2 (13) | c.9 (13) |
| Primary endpoint | Clinically significant UGI events | Complicated ulcers |
| Secondary endpoint | Complicated events | Clinically significant ulcers |
| Analysis | ITT (life table) | Crude, censored (3 days–6 months) |