Association of UGT1A7 polymorphisms with colorectal carcinoma
| UGT1A7 alleles | Normal controls† (n=210) (%) | Colorectal cancer† (n=78) (%) | p Value | OR (95% CI) |
|---|---|---|---|---|
| The wild-type allele of UGT1A7 was significantly more prevalent in the tumour free control group (OR 0.39, 95% CI 0.17–0.92). The association of polymorphic UGT1A7 alleles with colorectal cancer was significant for the UGT1A7*3/*1 and the UGT1A7*3/*2 genotypes. When the data were analysed for the presence of UGT1A7*3 alleles a highly significant association with colorectal cancer (CRC) was found. This analysis identified the presence of the UGT1A7*3 allele as a risk factor for CRC. The frequency of the UGT1A7*3 allele was 0.17 in normal controls and 0.301 in CRC patients. | ||||
| p values calculated by two tailed Fisher's exact test. | ||||
| OR, odds ratio; CI, confidence interval; NS, not significant. | ||||
| †All patients were of Northern German Caucasoid descent. | ||||
| UGT1A7*1/*1 | 42 (20) | 7 (9) | 0.03 | 0.39 (0.17–0.92) |
| UGT1A7*2/*1 | 52 (25) | 13 (17) | 0.15 | |
| UGT1A7*2/*2 | 25 (12) | 4 (5) | 0.12 | |
| UGT1A7*3/*1 | 20 (10) | 15 (19) | 0.04 | 2.26 (1.09–4.68) |
| UGT1A7*3/*2 | 19 (9) | 15 (19) | 0.02 | 2.39 (1.15–4.99) |
| UGT1A7*3/*3 | 17 (8) | 8 (10) | 0.63 | |
| UGT1A7*4/*1 | 35 (17) | 15 (19) | 0.60 | |
| UGT1A7*4/*3 | 0 | 1 (1) | NS | |
| UGT1A7*4/*4 | 0 | 0 | NS | |
| Presence of UGT1A7*3 | 56 (27) | 39 (50) | <0.001 | 2.75 (1.6–4.71) |