Table 1

Association of UGT1A7 polymorphisms with colorectal carcinoma

UGT1A7 allelesNormal controls† (n=210) (%)Colorectal cancer† (n=78) (%)p ValueOR (95% CI)
The wild-type allele of UGT1A7 was significantly more prevalent in the tumour free control group (OR 0.39, 95% CI 0.17–0.92). The association of polymorphic UGT1A7 alleles with colorectal cancer was significant for the UGT1A7*3/*1 and the UGT1A7*3/*2 genotypes. When the data were analysed for the presence of UGT1A7*3 alleles a highly significant association with colorectal cancer (CRC) was found. This analysis identified the presence of the UGT1A7*3 allele as a risk factor for CRC. The frequency of the UGT1A7*3 allele was 0.17 in normal controls and 0.301 in CRC patients.
p values calculated by two tailed Fisher's exact test.
OR, odds ratio; CI, confidence interval; NS, not significant.
†All patients were of Northern German Caucasoid descent.
UGT1A7*1/*142 (20) 7 (9) 0.030.39 (0.17–0.92)
UGT1A7*2/*152 (25)13 (17) 0.15
UGT1A7*2/*225 (12) 4 (5) 0.12
UGT1A7*3/*120 (10)15 (19) 0.04 2.26 (1.09–4.68)
UGT1A7*3/*219 (9)15 (19) 0.02 2.39 (1.15–4.99)
UGT1A7*3/*317 (8) 8 (10) 0.63
UGT1A7*4/*135 (17)15 (19) 0.60
UGT1A7*4/*3 0 1 (1)NS
UGT1A7*4/*4 0 0NS
Presence of UGT1A7*356 (27)39 (50)<0.0012.75 (1.6–4.71)