Influence of smoking and sex on type, site, and extent of familial inflammatory bowel disease.
| Smokers at diagnosis | ||
|---|---|---|
| Females (n=151) | Males (n=98) | |
| Values are odds ratios (95% confidence limits). | ||
| Patients were stratified by diagnosis, sex, and smoking habit. Female smokers at diagnosis were compared with female non-smoking relatives. Male smokers at diagnosis were compared with male non-smoking relatives. Female smokers were significantly more likely to develop Crohn's disease (CD) (p<0.001), particularly with colonic involvement (p=0.003), and less likely to develop ulcerative colitis (UC) (p<0.001) than male smokers (*p<0.05, **p<0.005, ***p<0.0001). | ||
| CD | 5.44 (3.33–8.88)*** n=122 | 2.11 (1.26–3.52)** n=58 |
| Ileal disease | 1.38 (0.71–2.71) n=94 | 3.68 (1.42–9.52)** n=49 |
| Ileo-caecal disease | 1.86 (0.92–3.77) n=99 | 1.54 (0.47–5.02) n=51 |
| Colonic disease | 1.17 (0.66–2.1) n=68 | 0.27 (0.13–0.58)** n=19 |
| Fibrostenosing disease | 1.83 (1.03–3.24)* n=75 | 2.49 (1.17–5.29)* n=38 |
| Perforating disease | 0.99 (0.51–1.91) n=28 | 1.07 (0.44–2.58) n=12 |
| Intestinal resection | 2.12 (1.17–3.86)* n=96 | 1.47 (0.69–3.13) n=38 |
| UC | 0.18 (0.11–0.3)*** n=29 | 0.47 (0.28–0.79)** n=40 |
| Pancolitis | 1.34 (0.59–3.04) n=16 | 1.21 (0.58–2.55) n=20 |
| Colectomy | 0.95 (0.38–2.35) n=8 | 1.06 (0.44–2.59) n=9 |