Frequencies of HLA-DRB, DQB1 alleles and tumour necrosis factor alpha promoter gene (TNFA) genotypes in patients with primary sclerosing cholangitis (PSC) and healthy controls
| PSC patients (n=63) | Healthy controls (n=83) | p Value | |
|---|---|---|---|
| *Only 56 patients with PSC were typed for HLA-DQB1. | |||
| Numbers in parentheses are percentages. | |||
| DRB1*03 | 12 (19) | 23 (28) | |
| DRB1*13 | 33 (52) | 17 (20) | 0.00009 |
| DRB3 | 53 (84) | 62 (75) | |
| DQB1*02 * | 20 (36) | 41 (49) | |
| DQB1*06 * | 33 (59) | 34 (41) | 0.04 |
| TNFA*1/TNFA*1 | 41 (65) | 63 (76) | |
| TNFA*1/TNFA*2 | 21 (33) | 19 (23) | |
| TNFA*2/TNFA*2 | 1 (2) | 1 (1) | |
| TNFA*2 allele carriage | 22 (27) | 20 (35) | |