Peripheral blood urease specific IgG and IgA antibody secreting cells (ASC) by treatment group
Antiurease IgG secreting cells positive/total volunteers* | Antiurease IgG peak ASC median† (range) [day to peak] | Antiurease IgA secreting cells positive/total volunteers* | Antiurease IgA peak ASC median† (range) [day to peak] | |
---|---|---|---|---|
*Positive status defined as ≥15 urease specific ASC/106 peripheral blood lymphocytes. †Highest count of urease specific ASC/106 peripheral blood lymphocytes between day 7 and day 73. Positive results only. | ||||
Group 1: Soluble urease, no LT | 1/6 | 80 [73] | 1/6 | 30 [73] |
Group 2: Soluble urease, 0.1 μg LT | 1/6 | 129 [73] | 2/6 | 35 (30–39) [69] |
Group 3: Soluble urease, 0.5 μg LT | 1/6 | 130 [64] | 1/6 | 146 [64] |
Group 4: Soluble urease, 2.5 μg LT | 3/6 | 110 (40–139) [36] | 1/6 | 150 [36] |
Group 5: Urease capsule, no LT | 1/6 | 800 [64] | 1/6 | 299 [64] |
Group 6: Urease capsule, 0.1 μg LT | 1/6 | 70 [64] | 1/6 | 100 [64] |
Group 7: Urease capsule, 2.5 μg LT | 2/6 | 40 (40–40) [73] | 1/6 | 16 [44] |