Table 1

Percentage of patients with complete relief of dyspeptic symptoms at four weeks, shown as the percentage of all patients in each treatment arm (All) and also divided according to type of investigator

Patients with complete relief of symptoms
BOND (n=642)OPERA (n=606)BOND+OPERA (n=1248)
PCP, primary care physician; SG, specialist gastroenterologist.
The split in patients between PCP and SG was 34% and 66% in the BOND study compared with 8% and 92% in the OPERA study. The difference in treatment response between the two studies was statistically significant when comparing active treatment (omeprazole 10 mg and 20 mg) with placebo (p=0.006) as well as when comparing each active drug with placebo (omeprazole 20 mg, p=0.04; omeprazole 10 mg, p=0.005). When adjusting for the type of investigator however, the difference in treatment response was not statistically significant.
Omeprazole 20 mg once daily42%34%47%34%56%32%38%38%38%
Omeprazole 10 mg once daily43%49%40%29%15%30%36%44%34%