Table 3

Randomised, double blind, crossover trials of cisapride versus placebo in dyspepsia

ReferenceNo of patientsTrial period (weeks)Inclusion criteria: dyspepsia typePlacebo response rate (%)Cisapride response rate (%)Investigators' conclusionComments
Milo 198437162×3Dyspepsia/reflux 675EffectiveNo washout period
Creytens 198438162×3Dysmotility/reflux5694EffectiveNo washout period
Francois and De Nutte 198739342×3Epigastric pain/burning4182EffectiveWashout period. Period effect found
Deruyttere et al 19877562×3Dysmotility/reflux5575EffectiveNo washout period. Period effect found
Deruyttere et al 1987401282×3Dysmotility/reflux4377EffectiveNo washout period. Period effect found. Possible double publication
Goethals and van de Mierop 198741242×4Dysmotility/reflux2963EffectiveNo washout period. Period effect found
Hannon 19874222×3Dysmotility/reflux2764EffectiveNo washout period
Van Ganse and Reyntjens 19874282×1Dysmotility/reflux1388EffectiveNo washout period
Corinaldesi et al 198743122×2Dysmotility??Not effectiveNo washout period