Randomised, double blind, crossover trials of cisapride versus placebo in dyspepsia
| Reference | No of patients | Trial period (weeks) | Inclusion criteria: dyspepsia type | Placebo response rate (%) | Cisapride response rate (%) | Investigators' conclusion | Comments |
|---|---|---|---|---|---|---|---|
| Milo 198437 | 16 | 2×3 | Dyspepsia/reflux | 6 | 75 | Effective | No washout period |
| Creytens 198438 | 16 | 2×3 | Dysmotility/reflux | 56 | 94 | Effective | No washout period |
| Francois and De Nutte 198739 | 34 | 2×3 | Epigastric pain/burning | 41 | 82 | Effective | Washout period. Period effect found |
| Deruyttere et al 19877 | 56 | 2×3 | Dysmotility/reflux | 55 | 75 | Effective | No washout period. Period effect found |
| Deruyttere et al 198740 | 128 | 2×3 | Dysmotility/reflux | 43 | 77 | Effective | No washout period. Period effect found. Possible double publication |
| Goethals and van de Mierop 198741 | 24 | 2×4 | Dysmotility/reflux | 29 | 63 | Effective | No washout period. Period effect found |
| Hannon 19874 | 22 | 2×3 | Dysmotility/reflux | 27 | 64 | Effective | No washout period |
| Van Ganse and Reyntjens 198742 | 8 | 2×1 | Dysmotility/reflux | 13 | 88 | Effective | No washout period |
| Corinaldesi et al 198743 | 12 | 2×2 | Dysmotility | ? | ? | Not effective | No washout period |