Frequencies of different HFE genotypes in control subjects and patients with increased ferritin and/or transferrin saturation (values in parentheses are percentages)
| C282Y | H63D | S65C | Patients (n=296) | Controls (n=250) |
|---|---|---|---|---|
| ***p<0.001 compared with controls (Fisher’s exact test). | ||||
| +/+ | −/− | −/− | 84 (28.4)*** | 1 (0.4) |
| −/− | +/+ | −/− | 7 (2.4) | 7 (2.8) |
| +/− | +/− | −/− | 21 (7.1)*** | 2 (0.8) |
| +/− | −/− | +/− | 2 (0.7) | 1 (0.4) |
| −/− | +/− | +/− | 3 (1.0) | 1 (0.4) |
| +/− | −/− | −/− | 28 (9.5) | 26 (10.4) |
| −/− | +/− | −/− | 49 (16.6) | 40 (16.0) |
| −/− | −/− | +/− | 9 (3.0) | 6 (2.4) |
| −/− | −/− | −/− | 93 (31.4)*** | 166 (66.0) |