Table 2

Number of patients and controls with the C282Y and H63D HFE mutations, and allele frequencies of the S65C mutation in chromosomes without the amino acid substitution C282Y or H63D

C282YH63DNo of patients (n=296)No of controls (n=250)S65C alleles* (patients)S65C alleles* (controls)
*On chromosomes with neither the C282Y nor H63D allele.
**p=0.0449 (Fisher’s exact test).
+/+−/−841
−/−+/+77
+/−+/−212
+/−−/−3027 2/30 (0.067) 1/27 (0.037)
−/−+/−5241 3/52 (0.058) 1/41 (0.024)
−/−−/−102172 9/204 (0.044)6/344 (0.017)
14/286 (0.049)**8/412 (0.019)**