Number of patients and controls with the C282Y and H63D HFE mutations, and allele frequencies of the S65C mutation in chromosomes without the amino acid substitution C282Y or H63D
| C282Y | H63D | No of patients (n=296) | No of controls (n=250) | S65C alleles* (patients) | S65C alleles* (controls) |
|---|---|---|---|---|---|
| *On chromosomes with neither the C282Y nor H63D allele. | |||||
| **p=0.0449 (Fisher’s exact test). | |||||
| +/+ | −/− | 84 | 1 | − | − |
| −/− | +/+ | 7 | 7 | − | − |
| +/− | +/− | 21 | 2 | − | − |
| +/− | −/− | 30 | 27 | 2/30 (0.067) | 1/27 (0.037) |
| −/− | +/− | 52 | 41 | 3/52 (0.058) | 1/41 (0.024) |
| −/− | −/− | 102 | 172 | 9/204 (0.044) | 6/344 (0.017) |
| 14/286 (0.049)** | 8/412 (0.019)** | ||||