Renal function evaluated during four hours of standing and during maintenance of the supine position
| Supine | Standing | |
|---|---|---|
| Data are mean (SD) | ||
| *p<0.03, **p<0.01 compared with values measured while supine (Wilcoxon signed rank test); †p<0.03, ††p<0.05 compared with controls (Wilcoxon rank sum test). | ||
| A, aldosterone; AR, active renin; CLi, lithium clearance; DDNa, distal sodium delivery; DRNa, distal sodium reabsorption; DFRNa, distal fractional sodium reabsorption; FELi, fractional lithium excretion; FENa, fractional sodium excretion; FlNa, filtered sodium load; GFR, glomerular filtration rate; PFR, proximal tubular reabsorption of fluid; PTRNa, proximal tubular reabsorption of sodium; UNaV, urinary sodium excretion. | ||
| Plasma AR concentration (μU/ml) | ||
| Controls | 22.3 (11.5) | 41.5 (36.2)** |
| Cirrhosis | 18.1 (5.9) | 36.7 (37.2)** |
| Plasma A concentration (pg/ml) | ||
| Controls | 105.0 (55.0) | 167.8 (40.8)** |
| Cirrhosis | 77.9 (63.9) | 200.8 (81.2)** |
| GFR (ml/min) | ||
| Controls | 112.5 (15.9) | 119.2 (37) |
| Cirrhosis | 147 (22.8)†† | 145.6 (36.5)†† |
| UNaV (μEq/min) | ||
| Controls | 159 (105) | 148 (128) |
| Cirrhosis | 146 (81) | 135 (78) |
| FlNa (mEq/min) | ||
| Controls | 15.8 (2.1) | 16.8 (5.1) |
| Cirrhosis | 19.9 (6.0)†† | 19.8 (12.4)†† |
| FENa (%) | ||
| Controls | 1.09 (0.87) | 0.88 (0.20) |
| Cirrhosis | 0.73 (0.48) | 0.68 (0.10)† |
| CLi (ml/min) | ||
| Controls | 26.9 (21.0) | 20.4 (14.2) |
| Cirrhosis | 30.5 (10.2) | 21.6 (8.6)* |
| PFR (ml/min) | ||
| Controls | 85.1 (50.3) | 101.3 (59.6) |
| Cirrhosis | 116.49 (42.2) | 123.9 (39.5) |
| PTRNa (mEq/min) | ||
| Controls | 11.90 (1.9) | 13.97 (3.0) |
| Cirrhosis | 15.70 (4.1)†† | 16.85 (6.5)†† |
| FELi (%) | ||
| Controls | 24.4 (8.2) | 17.6 (9.0) |
| Cirrhosis | 20.8 (4.9) | 12.8 (4.4)**†† |
| DDNa (mEq/min) | ||
| Controls | 3.88 (2.50) | 2.87 (2.10) |
| Cirrhosis | 4.22 (1.48) | 2.94 (0.90) |
| DRNa (mEq/min) | ||
| Controls | 3.42 (1.5) | 2.72 (0.3) |
| Cirrhosis | 4.10 (1.3) | 2.81 (2.9) |
| DFRNa (%) | ||
| Controls | 95.6 (4.0) | 94.6 (1.1) |
| Cirrhosis | 97.1 (1.2) | 95.5 (1.0) |