Phenotypic analysis of intestinal intraepithelial T lymphocytes (IEL) after coculture with bacteria
| Control mucosa | Inflamed mucosa Crohn’s disease | |
|---|---|---|
| *p<0.05 versus blank; †p< 0.05 versus E coli. | ||
| Data are median (range) (four control individuals and eight Crohn’s disease patients). | ||
| TNF-α, tumour necrosis factor α. | ||
| CD3 (% of cells) | ||
| Blank | 15 (3–17) | 6 (2–13) |
| L casei | 17 (2–21) | 4 (1–7)*† |
| L bulgaricus | 13 (3–17) | 4 (1–10)† |
| E coli | 16 (5–19) | 6 (1–14) |
| CD4 (% of CD3) | ||
| Blank | 32 (15–69) | 50 (31–61) |
| L casei | 33 (14–53) | 36 (18–63)* |
| L bulgaricus | 29 (16–57) | 40 (24–56) |
| E coli | 29 (27–61) | 39 (24–71) |
| TNF-α (% of CD3) | ||
| Blank | 3 (1–17) | 49 (4–77) |
| L casei | 3 (2–9) | 23 (2–58)*† |
| L bulgaricus | 3 (1–8) | 35 (3–75)† |
| E coli | 5 (3–18) | 53 (3–73) |