Table 2

Parameters of β cell function

ISR5 (pmol min/m2)Slope5 (pmol min/m2/ mM)p6 (pmol m2/ mM)p4 (pmol min/m2)SDr (pmol min/m2)ISRtot (nmol/m2)
ISR5, insulin secretion at 5 mM glucose; Slope5, of the dose-response at 5 mM glucose; p6, parameter of the derivative component (eq 2); p4, amplitude of the 24 hour modulation (eq 1); SDr, standard deviation of the residual insulin secretion component (Sr(t), Eq. 3); ISRtot, 24 hour integral of insulin secretion. *p<0.02 or less versus control subjects. †0.08<p<0.12 versus control subjects.
Controls57 (5)43 (6)1327 (425)35 (11)32 (6)138 (11)
Cirrhotics175 (26)*112 (34)†5385 (1586)*84 (27)†108 (21)*295 (53)*