Gastric metronidazole transfer: effect of Helicobacter pylori, iodoacetamide, and pronase
| Values are mean (SD). | ||||
| *p<0.05 versus control. | ||||
| Intravenous drug | Omeprazole | Omeprazole | Omeprazole | Omeprazole |
| Gastric luminal solution | 0.9% saline | 0.9% saline | 0.9% saline | Pronase |
| Preparation | Normal | H pylori infected | Iodoacetamide | Normal |
| n | 8 | 8 | 8 | 8 |
| Gastric aspirate Cmax (mg/l) | 14.2 (2.7) | 13.9 (3.4) | 12.2 (3.7) | 20.5 (6.6)* |
| Gastric clearance (l/min) | 87 (14) | 84 (19) | 89 (28) | 145 (41)* |
| Gastric transfer fraction (%) | 7.1 (1.3) | 5.4 (1.4)* | 7.2 (2.1) | 9.9 (2.5)* |