Table 2

Associations between methylation and molecular features of colorectal cancer

Methylation (%)
Feature (n)p16MDR1MINT-2OneTwoThree
*p<0.2; †p<0.1; ‡p<0.05; §p<0.005.
MSI, microsatelite instability.
Total (275)100 (36)67 (24)102 (37)141 (51)88 (32)40 (15)
TP53
    Wild-type (152) 59 (39)40 (26) 62 (41) 79 (52)54 (36)28 (18)
    Mutant (103) 30 (29)*18 (18)† 26 (25)‡ 46 (44)21 (20)‡ 7 (7)‡
K-ras
    Wild-type (138) 51 (37)41 (30) 50 (36) 67 (46)49 (36)26 (19)
    Mutant (65) 17 (26)* 7 (11)§ 18 (28) 28 (44)11 (17)‡ 3 (5)‡
MSI
    − (228) 70 (31)40 (18) 70 (31)106 (45)58 (25)16 (7)
    + (41) 28 (68)§27 (66)§ 30 (73)§ 32 (77)§29 (71)§24 (59)§