Table 3

Characteristics of microsatellite instability (MSI+) colorectal cancer with or without hMLH1 methylation

hMLH1 (%)
Feature (n)UnmethylatedMethylatedp Value
*p16, MDR1, and MINT-2.
†Fisher’s exact test.
‡χ2 test.
Total (54)10 (19)44 (81)
Sex
    Female (33) 3 (9)30 (91)
    Male (21) 7 (33)14 (67) 0.035†
Age
    <68 y (27) 9 (33)18 (67)
    ≥68 y (27) 1 (4)26 (96) 0.005‡
Site
    Distal (4) 2 (50) 2 (50)
    Proximal (49) 7 (14)42 (86) 0.13†
Grade
    Well/moderate (31) 9 (29)22 (71)
    Poor (22) 1 (5)21 (95) 0.033†
TP53
    Wild-type (42) 9 (21)33 (79)
    Mutant (8) 1 (13) 7 (87) NS
K-ras
    Wild-type (41) 5 (12)36 (88)
    Mutant (8) 4 (50) 4 (50) 0.028†
CpG methylation*
    <2 sites (15)10 (67) 5 (33)
    ≥2 sites (34) 0 (0)34 (100)<0.001†