Table 5

Hepatic disposal of pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis

Cirrhosis (n = 51)Controls (n = 13)
Values are mean (SEM).
†Values in parentheses are corresponding values in the artery obtained simultaneously with the hepatic vein sample.
aSignificantly different from controls (p<0.05).
ProBNP
    Hepatic vein (pmol/l)17.7 (2.0)12,4 (5.0) (n = 5)
    (Artery, pmol/l)†(18.3) (2.1)†(14.6) (5.9)†
    Extraction ratio0.05 (0.038)0.09 (0.036) (n = 5)
    Clearance (ml/min)23 (45)22 (25)
    Disposal rate (pmol/min)0.73 (0.48)0.27 (0.17)
BNP
    Hepatic vein (pmol/l)10.1 (1.3)10.1 (3.3) (n = 8)
    (Artery, pmol/l)†(11.8 (1.4)†(12.3 (3.4)†
    Extraction ratio0.12 (0.026)0.18 (0.10) (n = 8)
    Clearance (ml/min)49 (15)68 (76) (n = 8)
    Disposal rate (pmol/min)1.41 (0.52)a0.46 (0.13) (n = 8)