IL-1B genotype frequencies in control subjects and gastric cancer (GC) patients in Guangdong (low prevalence region) and Shanxi (high prevalence region)
| Genotype | Guangdong (low prevalence region) | Shanxi (high prevalence region) | |||
|---|---|---|---|---|---|
| Controls (n = 192) | GC patients (n = 84) | Controls (n = 169) | GC patients (n = 86) | ||
| *CancerGuangdong versus controlGuangdong: χ2 = 6.7, p = 0.010, OR 2.3, 95% CI 1.2–4.5. | |||||
| †CancerGuangdong versus controlGuangdong: χ2 = 9.9, p = 0.002, OR 2.5, 95% CI 1.4–4.4. | |||||
| ‡ControlGuangdong versus controlShanxi: χ2 = 7.0, p = 0.008, OR 2.1, 95% CI 1.2–3.7. | |||||
| §CancerShanxi versus controlShanxi: χ2 = 5.0, p = 0.025, OR 2.4, 95% CI 1.1–5.2. | |||||
| IL-1B−511 | C/C | 87 | 18 | 34 | 19 |
| C/T | 78 | 45 | 97 | 45 | |
| T/T | 27 (14.1%) | 21 (25.0%) | 38 (22.5%) | 22 (25.6%) | |
| Sex adjusted T/T | (12.5%) | (25.0%)* | (23.0%)‡ | (23.1%) | |
| IL-1B−31 | C/C | 156 (81.3%) | 54 (64.3%) | 128 (75.7%) | 78 (90.7%) |
| Sex adjusted C/C | (82.1%) | (64.3%)† | (78.0%) | (90.0%)§ | |
| C/T | 35 | 27 | 34 | 4 | |
| T/T | 1 | 3 | 7 | 4 | |
| IL-B+3954 | C/C | 164 | 77 | 152 | 77 |
| C/T | 28 | 7 | 17 | 8 | |
| T/T | 0 | 0 | 0 | 1 (1.2%) | |