Table 3

Extra-colonic symptom scores

Symptoms	Pre-HT§		Pre-HT/Post-HT¶		Pre-HT/follow up¶
Symptoms	R	NR	R	NR	R	NR
Data shown for responders (R) and non-responders (NR) as §mean scores (SEM); ¶intra-individual differences (mean (95% CI)) between time points shown, with positive and negative values denoting reduction and increase in scores, respectively, relative to earlier time point.
p<0.05, p<0.005, **p<0.001 (versus pre-HT); †††p<0.001; ††p<0.01; †p<0.05; ‡p>0.05 (R v NR).
Nausea/vomiting	28.5 (2.3)‡	27.8 (3.8)	13.9 (10.4 to 17.4)***	11.4 (6.1 to 16.7)***	13.0 (9.5 to 16.5)***	11.5 (4.9 to 18.0)**
Early satiety	29.1 (2.3)‡	23.8 (3.8)	10.1 (6.8 to 13.4)***	6.5 (1.8 to 11.2)**	10.1 (5.8 to 14.5)***	6.9 (2.3 to 11.5)**
Heartburn	31.7 (2.4)‡	26.5 (3.9)	15.9 (11.7 to 20.2)*** ††	5.1 (−0.9 to 11.1)	10.5 (5.9 to 15.2)***	7.8 (1.9 to 13.7)*
Backache	49.7 (2.6)‡	41.6 (4.2)	16.9 (12.8 to 21.1)*** ††	4.5 (−1.7 to 10.7)	14.2 (9.7 to 18.6)*** †	3.7 (−3.7 to 11.0)
Headaches	41.6 (2.4)‡	35.7 (4.0)	13.3 (9.6 to 17.0)***	8.9 (3.5 to 14.3)**	9.4 (5.6 to 13.2)***	3.9 (−1.4 to 9.2)
Excess wind	74.2 (1.9)‡	74.6 (3.5)	33.7 (28.9 to 38.5)*** †††	19.2 (13.4 to 25.0)***	18.7 (14.1 to 23.3)*** †	9.6 (2.5 to 16.6)**
Lethargy	67.2 (2.3)‡	67.2 (3.6)	29.0 (24.5 to 33.5)*** ††	15.1 (7.7 to 22.5)***	16.4 (11.8 to 21.0)*** †	5.4 (−1.9 to 12.6)
Urinary	48.0 (2.8)‡	38.7 (4.4)	15.9 (11.5 to 20.4)*** ††	2.2 (−5.1 to 9.4)	6.2 (1.1 to 11.3)* †	−4.6 (−13.8 to 4.5)
Thigh pain	24.3 (2.5)‡	24.9 (4.6)	10.3 (6.1 to 14.5)***	7.6 (1.1 to 14.1)*	4.5 (−0.5 to 9.4)*	3.2 (−4.4,10.8)
Bodily aches	47.9 (2.7)‡	46.4 (4.6)	16.6 (12.0 to 21.3)*** †	6.9 (−0.6 to 13.9)	6.5 (1.4 to 11.6)*	0.4 (−7.2 to 8.0)
Overall score	219.5 (7.6)‡	201.1 (11.5)	80.4 (65.1 to 95.6)*** †††	40.1 (24.5 to 55.6)***	53.7 (41.1 to 66.2)*** ††	21.6 (7.6 to 35.5)**