Cholecystokinin (CCK) induced gall bladder emptying and postprandial gall bladder emptying
| Hypertriglyceridaemic patients | ||||
|---|---|---|---|---|
| Controls | Baseline | Bezafibrate | Fish oil | |
| Values are mean (SEM). | ||||
| **p<0.01compared with hypertriglyceridaemic patients at baseline; †p<0.05 compared with hypertriglyceridaemic patients on bezafibrate therapy. | ||||
| CCK induced gall bladder emptying | ||||
| Fasting gall bladder volume (ml) | 21.3 (1.8) | 18.5 (2.2) | 17.1 (1.6) | 19.1 (1.9) |
| Residual gall bladder volume (ml) | 2.2 (0.3) | 4.2 (1.0) | 2.1 (0.5) | 3.4 (1.0) |
| Gall bladder emptying over 45 min (%) | 58 (3)** | 45 (2) | 58 (2)** | 51 (2)† |
| Maximum gall bladder emptying (%) | 90 (17) | 76 (6) | 87 (3) | 82 (4) |
| Fasting CCK levels (pmol/l) | 0.5 (0.2) | 1.1 (0.1) | 1.1 (0.2) | 0.8 (0.2) |
| Integrated incremental CCK levels (pM×45min) | 375 (73) | 409 (72) | 495 (76) | 506 (105) |
| Postprandial gall bladder emptying | ||||
| Fasting gall bladder volume (ml) | 22.6 (1.6) | 19.0 (1.5) | 20.9 (2.6) | 22.4 (2.3) |
| Residual gall bladder volume (ml) | 8.4 (1.3)** | 11.9 (1.1) | 8.5 (1.5)** | 10.4 (1.4) |
| Gall bladder emptying over 120 min | 32 (2)** | 20 (2) | 30 (2)** | 25 (2)**† |
| Maximum gall bladder emptying (%) | 64 (4)** | 35 (6) | 61 (14)** | 50 (7) |
| Fasting CCK levels (pmol/l) | 0.2 (0.1) | 0.9 (0.4) | 0.7 (0.2) | 0.9 (0.3) |
| Maximum CCK levels (pmol/l) | 2.9 (0.3) | 3.4 (0.4) | 3.8 (0.3) | 3.7 (0.3) |
| Maximum CCK increase (pmol/l) | 2.7 (0.3) | 2.5 (0.3) | 3.2 (0.3) | 2.9 (0.3) |
| Integrated incremental CCK levels (pM×120 min) | 168 (32) | 272 (42) | 329 (45) | 302 (42) |