Factors associated with moderate or severe fibrosis (univariate analysis)
| Fibrosis F0–F1 (n=181) | Fibrosis F2–F4 (n=109) | p Value | |
|---|---|---|---|
| *Results are expressed as mean (SD). | |||
| BMI, body mass index; ALT, alanine aminotransferase; HCV, hepatitis C virus. | |||
| Sex (male, n (%)) | 80 (44) | 63 (58) | 0.02 |
| Age (n (%)) | <0.0001 | ||
| <50 y | 133 (73) | 49 (45) | |
| ⩾50 y | 48 (27) | 60 (55) | |
| Age at infection (n (%)) | 0.05 | ||
| <30 y | 89 (49) | 38 (35) | |
| ⩾30 y | 16 (9) | 15 (14) | |
| Unknown | 76 (42) | 56 (51) | |
| Source of infection (n (%)) | 0.2 | ||
| Blood transfusion | 44 (24) | 26 (24) | |
| Intravenous drug use | 63 (35) | 28 (26) | |
| Unknown | 74 (41) | 55 (50) | |
| Duration of infection (y)* | 20.3 (7.6) | 22.2 (7.6) | 0.15 |
| Body mass index (kg/m2) (n (%)) | 0.002 | ||
| Normal (BMI <25) | 122 (67) | 49 (45) | |
| Overweight (25⩽BMI<30) | 39 (22) | 39 (36) | |
| Obese (BMI ⩾30) | 9 (5) | 11 (10) | |
| Unknown | 11 (6) | 10 (9) | |
| Alcohol consumption (n (%)) | 0.79 | ||
| Absent | 121 (67) | 69 (63) | |
| Present | 55 (30) | 36 (33) | |
| Unknown | 5 (3) | 4 (4) | |
| Tobacco consumption (n (%)) | 0.19 | ||
| Absent | 91 (50) | 63 (58) | |
| Present | 80 (44) | 37 (34) | |
| Unknown | 10 (6) | 9 (8) | |
| ALT (IU/l, median) | 65 (81) | 105 (83) | <0.0001 |
| Glycaemia (mmol/l) | 5.2 (1.7) | 5.5 (1.8) | 0.14 |
| Cholesterol (mmol/l) | 4.9 (1.2) | 4.7 (0.9) | 0.12 |
| Triglyceride (mmol/l) | 1.1 (0.7) | 1.3 (0.7) | 0.17 |
| HCV genotype (n (%)) | 0.41 | ||
| 3 | 33 (18) | 18 (17) | |
| Other | 119 (66) | 79 (72) | |
| Unknown | 29 (16) | 12 (11) | |
| Grade (histology) (n (%)) | <0.0001 | ||
| A0–A1 | 162 (90) | 50 (46) | |
| A2–A3 | 19 (10) | 59 (54) | |
| Steatosis (histology) (n (%)) | 0.0005 | ||
| Absent | 111 (61) | 44 (40) | |
| Present | 70 (39) | 65 (60) | |