Table 5

Factors associated with moderate or severe fibrosis (univariate analysis)

Fibrosis F0–F1 (n=181)Fibrosis F2–F4 (n=109)p Value
*Results are expressed as mean (SD).
BMI, body mass index; ALT, alanine aminotransferase; HCV, hepatitis C virus.
Sex (male, n (%))80 (44)63 (58)0.02
Age (n (%))<0.0001
    <50 y133 (73)49 (45)
    ⩾50 y48 (27)60 (55)
Age at infection (n (%))0.05
    <30 y89 (49)38 (35)
    ⩾30 y16 (9)15 (14)
    Unknown76 (42)56 (51)
Source of infection (n (%))0.2
    Blood transfusion44 (24)26 (24)
    Intravenous drug use63 (35)28 (26)
    Unknown74 (41)55 (50)
Duration of infection (y)*20.3 (7.6)22.2 (7.6)0.15
Body mass index (kg/m2) (n (%))0.002
    Normal (BMI <25)122 (67)49 (45)
    Overweight (25⩽BMI<30)39 (22)39 (36)
    Obese (BMI ⩾30)9 (5)11 (10)
    Unknown11 (6)10 (9)
Alcohol consumption (n (%))0.79
    Absent121 (67)69 (63)
    Present55 (30)36 (33)
    Unknown5 (3)4 (4)
Tobacco consumption (n (%))0.19
    Absent91 (50)63 (58)
    Present80 (44)37 (34)
    Unknown10 (6)9 (8)
ALT (IU/l, median)65 (81)105 (83)<0.0001
Glycaemia (mmol/l)5.2 (1.7)5.5 (1.8)0.14
Cholesterol (mmol/l)4.9 (1.2)4.7 (0.9)0.12
Triglyceride (mmol/l)1.1 (0.7)1.3 (0.7)0.17
HCV genotype (n (%))0.41
    333 (18)18 (17)
    Other119 (66)79 (72)
    Unknown29 (16)12 (11)
Grade (histology) (n (%))<0.0001
    A0–A1162 (90)50 (46)
    A2–A319 (10)59 (54)
Steatosis (histology) (n (%))0.0005
    Absent111 (61)44 (40)
    Present70 (39)65 (60)