Baseline characteristics of the normal ALT group and the raised ALT group
| Normal ALT group (n=52) | Raised ALT group (n=53) | p Value | |
|---|---|---|---|
| BMI, body mass index; ALB, albumin; BIL, bilirubin; ALT, alanine aminotransaminase; AST, aspartate aminotransaminase; ALP, alkaline phosphatase; HCV, hepatitis C virus; IV, intravenous. | |||
| Values are median (interquartile range 25th–75th percentile) or number. | |||
| Age (y) | 47.5 (43.3–52) | 49 (43–51.5) | 0.90 |
| Sex (M:F) | 46:6 | 47:6 | 1.00 |
| Genotype | 0.55 | ||
| 1 | 33 | 33 | |
| 2 | 9 | 6 | |
| 3 | 6 | 9 | |
| Indeterminate | 4 | 5 | |
| BMI (kg/m2) | 28.2 (25.4–29.2) | 25.5 (21.4–31.7) | 0.35 |
| ALB (g/l) | 4 (3.8–4.2) | 4 (3.8–4.1) | 0.46 |
| BIL (mg/dl) | 0.8 (0.5–0.9) | 0.7 (0.6–0.9) | 0.60 |
| ALT (U/l) | 45 (32.5–53) | 132.5 (109–179.8) | <0.0001 |
| AST (U/l) | 46 (37–52) | 92.5 (73.5–139) | <0.0001 |
| ALP (U/l) | 69 (57.3–87.3) | 68 (54–87) | 0.47 |
| HCV RNA (IU/ml) | 420 000 (83 000–>850 000) | 530 000 (50 570–>850 000) | 0.60 |
| Race | 0.16 | ||
| Caucasian | 16 | 20 | |
| African American | 5 | 1 | |
| Other | 1 | 4 | |
| Decline to answer | 30 | 28 | |
| Education | 0.63 | ||
| College | 17 | 18 | |
| High school | 5 | 6 | |
| Elementary school | 0 | 1 | |
| Decline to answer | 30 | 28 | |
| Annual income | 0.07 | ||
| >$50 000 | 1 | 4 | |
| $25 000–$50 000 | 4 | 7 | |
| $10 000–$25 000 | 9 | 2 | |
| <$10 000 | 7 | 7 | |
| Decline to answer | 31 | 33 | |
| Risk for infection | 0.10 | ||
| Transfusion | 15 | 26 | |
| IV drug abuse | 20 | 14 | |
| Unknown | 17 | 13 | |
| Stage of fibrosis | 0.04 | ||
| F0–F1 | 24 | 14 | |
| F2–F3 | 28 | 39 | |
| Necroinflammatory grade | 0.17 | ||
| A0–1 | 11 | 6 | |
| A2–3 | 41 | 47 | |