Steady state pharmacokinetic parameters following oral administration of naproxen (500 mg twice daily) and AZD3582 (750 mg twice daily)
| Parameter | AZD3582 | Naproxen | |
|---|---|---|---|
| AZD3582 | Naproxen | Naproxen | |
| Values are (mean (SD)). | |||
| AUC, area under the curve; Css,max, maximum plasma concentrations at steady state; Css,min, minimum plasma concentrations at steady state; tmax, time of maximum plasma concentration. | |||
| AUCss (h×µmol/l) | Not quantifiable | 3347 (462) | 3624 (679) |
| tmax (h) | 2.01 (1.06) | 2.70 (1.23) | 1.87 (0.62) |
| Css,max (µmol/l) | 0.020 (0.017) | 360 (43) | 466 (75) |
| Css,min (µmol/l) | <0.004 | 248 (51) | 240 (59) |