Adjusted odds ratios (OR) and 95% confidence limits (CL) for birth outcome in patients treated with 5-aminosalicylic acid (5-ASA) in pregnancy, stratified by type of underlying disease (Crohn's disease or ulcerative colitis)
| Patients with Crohn's disease treated with 5-ASA | Patients with ulcerative colitis treated with 5-ASA | |||
|---|---|---|---|---|
| Events/total (%) | OR (adjusted‡) (95% CL) | Events/total (%) | OR (adjusted‡) (95% CL) | |
| *LBW, birth weight less than 2500 g. | ||||
| **Preterm birth, gestational age less than 37 weeks. | ||||
| †Different exposure window when examining congenital malformations (exposed in the period 30 days before conception to the end of first trimester). | ||||
| ‡Adjusted for mother's age (below 25 years, 25–29 years, and 30 years or more), parity (1 or more than 1), smoking (yes/no) in a logistic regression model. LBW and stillbirths also for gestational age (32 weeks or less, 33–36 weeks, and 37 weeks or more). | ||||
| LBW* | 1/23 (4.3) | 0.9 (0.1–6.7) | 3/65 (4.6) | 1.4 (0.4–4.3) |
| Preterm birth** | 1/23 (4.3) | 0.8 (0.1–5.6) | 7/65 (10.8) | 2.4 (1.1–5.3) |
| Stillbirth | 0/23 (0.0) | — | 3/65 (4.6) | 8.4 (2.0–34.3) |
| Malformation† | 1/18 (5.6) | 1.5 (0.2–11.4) | 3/42 (7.1) | 2.1 (0.7–6.9) |