Table 4

Reduction in anal pressure with dose-response to glyceryl trinitrate (GTN)

Treatment groupBaseline anal resting pressurePressure change after 4 weeks on treatmentPressure change after 8 weeks on treatment
Values are mean (SD) cm H2O.
    Placebo110.9 (49.2) (n=9)−0.9 (14. 2) (n=8)−12 (26.2) (n=6)
    0.1% GTN110.5 (61.3) (n=11)+4.4 (17.2) (n=11)−12.3 (22.7) (n=10)
    0.2% GTN 88.2 (46.5) (n=11)−5.7 (10.6) (n=11)−11.8 (32.9) (n=9)
    0.4% GTN101.7 (56.2) (n=7)−7.7 (15.9) (n=7)−20.3 (24.9) (n=7)