Reduction in anal pressure with dose-response to glyceryl trinitrate (GTN)
| Treatment group | Baseline anal resting pressure | Pressure change after 4 weeks on treatment | Pressure change after 8 weeks on treatment |
|---|---|---|---|
| Values are mean (SD) cm H2O. | |||
| Placebo | 110.9 (49.2) (n=9) | −0.9 (14. 2) (n=8) | −12 (26.2) (n=6) |
| 0.1% GTN | 110.5 (61.3) (n=11) | +4.4 (17.2) (n=11) | −12.3 (22.7) (n=10) |
| 0.2% GTN | 88.2 (46.5) (n=11) | −5.7 (10.6) (n=11) | −11.8 (32.9) (n=9) |
| 0.4% GTN | 101.7 (56.2) (n=7) | −7.7 (15.9) (n=7) | −20.3 (24.9) (n=7) |